New and emerging treatments for acne and photoaging

Journal of Drugs in Dermatology, Jan, 2006

by Macrene Alexiades-Armenakas

At this year’s annual meeting of the American Society for Dermatologic Surgery, which took place in Atlanta, Georgia on October 27-30, 2005, investigators provided new insights into the treatment of the common conditions of acne and photoaging. The imminent regulation of isotretinoin by the FDA under the new iPLEDGE program, which will be required as of March 1, 2006, has necessitated the search for alternative forms of acne treatment. Laser treatments of acne in the recent past have included the blue light (Clearlight, Lumenis) and the diode laser (Smoothbeam, Candela), both of which achieved FDA clearance but have yielded moderate results. Controversy exists over the efficacy of low fluence pulsed dye laser therapy for acne. At this meeting, the work of the author and others indicate that aminolevulinic acid combined with pulsed dye laser, blue light, or intense pulsed light may be a safe and highly effective treatment alternative for acne of all types and levels of severity. In addition, difficult follicular occlusion diseases such as hidradenitis suppurativa were effectively treated with photodynamic therapy. Further work using infrared lasers for acne demonstrated that the 1320-nm laser at longer pulse durations in the 100-200 ms range allowed for higher fluences and improved lesional clearance rates.

Thus, laser and light-based treatments and photodynamic therapy are emerging as important treatment options for acne…

Sonuç olarak akne için lazer ve ışığa dayalı tedavilerle fotodinamik tedavinin önemli seçenekler olduğu gündeme gelmektedir.


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