Azelaic acid içeren birkaç ürün var ülkemizde. skinoren krem azelderm krem finacea jel. Antibakteriyel, keratolitik ve pigment azaltıcı etkileri saptanmış olsa da benim acizane deneyimim bu etkinliklerde diğer seçeneklerle karşılaştırılamayacak ölçüde
zayıf olduğu. ama bir alternatif olarak elimizin altında olması güzel.
Oldukça tecrübeli bir meslektaşla yazışmamda (Prof. Haines Ely) azelaic acidin
birlikte kullanıldığı ilacın deriye nüfuzunu en iyi artıran molekül olduğunu öğrendim.

AZELAİC ACİD

Antibacterial: it reduces the growth of bacteria in the follicle (Propionibacterium acnes and Staphylococcus epidermidis).

Keratolytic & comedolytic: it returns to normal the disordered growth of the skin cells, lining the follicle.
Scavenger of free radicals and reduces inflammation.

Reduces pigmentation: it is particularly useful for darker-skinned patients, who have melasma, or whose acne spots leave persistent brown marks known as actinic lentigenes (per the product insert: “There have been reports of hypopigmentation after use of azelaic acid. Since azelaic acid has not been well studied in patients with dark complexions, these patients should be monitored for early signs of hypopigmentation.”).
Non-toxic, and is well tolerated by most patients.

Azelaic acid does not result in:

Bacterial resistance to antibiotics.
Reduction in sebum production.
Photosensitivity (easy sunburn).
Staining of skin or clothing.
Bleaching of normal skin or clothing.
Because 20% azelaic acid can be a skin irritant, it should be used only when prescribed by a physician.

Uses of azelaic acid

Acne treatment

Azelaic acid is used to treat mild to moderate acne, i.e. both comedonal acne and inflammatory acne. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. [1] It is also used as a topical treatment for Rosacea, due to its ability to reduce inflamation. In some cases, females have reported hair growth on face and neck.

Rosacea Treatment

Azelaic acid cream applied topically. Brand Names: Azelex, Finacea, Finevin

Hair loss

Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it, with zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor.[2] The enzyme, 5-AR (both Types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles. However, no clinical studies have confirmed its efficacy in helping with hair loss.

2 YORUMLAR

  1. Azelaic asid ile ilgili araştırma yaparken sitenizle karşılaştım. 3 yaşındaki kız torunumda çok az miktarda(birkaç cm2) olmakla birlikte vitiligo lekeleri belirdi.Doktor tavsiyesine uygun tedavisi sürüyor.Azelaic asid içerikli krem -jel kullanmak uygun olabilir mi sizce?Ya da bu konuda tavsiyeleriniz olabilir mi?
    Saygılarımızla,

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