High-dose intravenous corticosteroid pulse therapy in alopecia areata: Own experience compared with the literature.Luggen P, Hunziker T.
Department of Dermatology, University of Bern, Switzerland.

Background: Seven prospective studies including 193 patients have been published on high-dose intravenous corticosteroid pulse therapy in alopecia areata (AA).We compare these data with a retrospective analysis of our own consecutive patients. Patients and Methods: Between 1998 and 2002,25 patients with severe AA were treated at the Department of Dermatology, University of Bern, with infusions of 500 mg methylprednisolone on 3 consecutive days.In addition to the inpatient records, in 2004 all patients were followed up by a questionnaire. Results: Four of 10 patients with multifocal AA and 3 of 9 patients with ophiasis-type AA had full re-growth of hair, whereas all 6 patients with AA totalis/universalis failed to respond. Conclusion: Intravenous corticosteroid pulse therapy may be helpful in the treatment of multifocal and ophiasis-type AA.Patients with an initial episode of short duration have better chances for success.

İsviçreden bir çalışma

…Saçkıran adıyla da bilinen alopecia areatanın şiddetli formlarında çok yüksek doz kortizonu ayda 3 gün pulse şeklinde vererek yapılan tedavi bazı hastalarda
faydalı olabiliyor. ilk atak sırasında tedaviye başlamak daha iyi sonuç vermiş.

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