Kanada Toronto Üniversitesinde yapılan bir araştırmaya göre (mayıs2008) Gingko biloba tek başına bile vitiligo tedavisnde ümit vadediyor…

A systematic review of natural health product treatment for vitiligo

Orest Szczurko and Heather S Boon

Leslie Dan Faculty of Pharmacy, University of Toronto, Canada

Further clinical research in the treatment of vitiligo is necessary. Two areas are particularly intriguing. First, well designed clinical trials should attempt to replicate the studies utilizing L-phenylalanine in conjunction with phototherapy treatment. Several small clinical trials published so far provide positive results consistently with replication, but larger more definitive trials are necessary. Second, the use of Ginkgo biloba alone for the treatment of vitiligo holds potential promise. The use of Gingko biloba without phototherapy is likely to avoid the adverse reactions and unknown long term risks associated with phototherapy. If effective, Ginko biloba would also be a less costly and easier treatment for vitiligo. Parsaud’s trial is methodologically sound, and provides promising results. However, one published trial is not enough evidence to impact clinical practice. The need to find a safe and effective treatment is particularly important with vitiligo, where up to 50% of cases develop in the paediatric population; at a time when the condition has the greatest impact on psychological development.

Reports investigating the efficacy of NHPs for vitiligo exist, but are of poor methodological quality and contain significant reporting flaws. Most trials use NHPs as an adjunct to UVA or UVB phototherapy. There are few controlled trials assessing efficacy of NHPs for vitiligo, but those that have been published generally show weakly positive outcomes with few adverse reactions. L-phenylalanine used with phototherapy shows promise. The use of oral Ginkgo biloba as monotherapy for vitiligo is also promising. Ginkgo’s apparent efficacy without the need for phototherapy, thus eliminating the adverse events inherent with phototherapy make it a therapeutic option worth investigating. Further high quality investigations into the use of NHPs in the treatment of vitiligo, particularly L-phenylalanine and Ginkgo biloba are needed.


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